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L-Epinephrine

Cat. No. M13894
L-Epinephrine Structure
Synonym:

(-)-Epinephrine; L-Adrenaline; (-)-Adrenalin

Size Price Availability Quantity
500mg USD 65  USD65 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

L-Epinephrine is a hormone secreted by the medulla of the adrenal glands. L-Epinephrine is an α-adrenergic and β-adrenergic receptor agonist.

*The compound is unstable in solutions, freshly prepared is recommended



Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 183.2
Formula C9H13NO3
CAS Number 51-43-4
Purity >99%
Solubility DMSO 2.22 mg/mL
Water 2 mg/mL (ultrasonic and adjust pH to 2 with HCl)
Storage 2-8°C, protect from light, sealed
References

[1] Meredith C Winter, et al. A New Trick for an Old Dog: L-Epinephrine Delivered Continuously in the Vapor Phase

[2] No authors listed. Epinephrine

[3] Kitty Leung, et al. Delivery of Epinephrine in the Vapor Phase for the Treatment of Croup

[4] Candice Bjornson, et al. Nebulized epinephrine for croup in children

[5] Candice Bjornson, et al. Nebulized epinephrine for croup in children

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Keywords: L-Epinephrine, (-)-Epinephrine; L-Adrenaline; (-)-Adrenalin supplier, Adrenergic Receptor, inhibitors

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