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L-carnitine

Cat. No. M3580
L-carnitine Structure
Synonym:

Levocarnitine

Size Price Availability Quantity
1g USD 198  USD220 In stock
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Biological Activity

L-carnitine (Levocarnitine) is constituent of striated muscle and liver.It is used therapeutically to stimulate gastric and pancreatic secretions and in the treatment of hyperlipoproteinemias.. Vitamin C (ascorbic acid) is essential to the synthesis of carnitine. Levocarnitine is a carrier molecule in the transport of long chain fatty acids across the inner mitochondrial membrane. Only the L isomer of carnitine (sometimes called vitamin BT) affects lipid metabolism. Levocarnitine is handled by several proteins in different pathways including carnitine transporters, carnitine translocases, carnitine acetyltransferases and carnitine palmitoyltransferases.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 161.2
Formula C7H15NO3
CAS Number 541-15-1
Purity >98%
Solubility DMSO 10mg/mL
Water 30mg/mL
Ethanol 30 mg/mL
Storage 4°C, dry, sealed
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  Catalog
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Keywords: L-carnitine, Levocarnitine supplier, Estrogen Receptor, inhibitors

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