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Kaempferol 7-O-rhamnoside

Cat. No. M16619
Kaempferol 7-O-rhamnoside Structure
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Biological Activity

Kaempferol 7-O-rhamnoside

Chemical Information
CAS Number 20196-89-8
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Ji Hye Kim, et al. Int J Mol Sci. Kaempferol and Its Glycoside, Kaempferol 7-O-Rhamnoside, Inhibit PD-1/PD-L1 Interaction In Vitro

[2] Jonathon Roepke, et al. Phytochemistry. Arabidopsis thaliana β-glucosidase BGLU15 attacks flavonol 3-O-β-glucoside-7-O-α-rhamnosides

[3] Ruohe Yin, et al. New Phytol. Kaempferol 3-O-rhamnoside-7-O-rhamnoside is an endogenous flavonol inhibitor of polar auxin transport in Arabidopsis shoots

[4] R D Vierstra, et al. Plant Physiol. Kaempferol 3-O-Galactoside, 7-O-Rhamnoside is the Major Green Fluorescing Compound in the Epidermis of Vicia faba

[5] Raymond E March, et al. Rapid Commun Mass Spectrom. A fragmentation study of a flavone triglycoside, kaempferol-3-O-robinoside-7-O-rhamnoside

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