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Kaempferol 3-O-sophoroside

Cat. No. M16610
Kaempferol 3-O-sophoroside Structure
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Biological Activity

Kaempferol 3-O-sophoroside

Chemical Information
CAS Number 19895-95-5
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Jun-Jie Xiang, et al. Zhongguo Zhong Yao Za Zhi. [Analysis of flavonoids from saffron floral bio-residues]

[2] Christoph Hald, et al. J Agric Food Chem. Kaempferol 3- O-(2‴- O-Sinapoyl-β-sophoroside) Causes the Undesired Bitter Taste of Canola/Rapeseed Protein Isolates

[3] Tae Hoon Kim, et al. Food Chem Toxicol. Inhibitory effects of kaempferol-3-O-sophoroside on HMGB1-mediated proinflammatory responses

[4] Tae Hoon Kim, et al. Inflamm Res. Anti-inflammatory effects of kaempferol-3-O-sophoroside in human endothelial cells

[5] S Palanichamy, et al. J Ethnopharmacol. Analgesic activity of Cassia alata leaf extract and kaempferol 3-o-sophoroside

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