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Kaempferide

Cat. No. M4369
Kaempferide Structure
Synonym:

Kaempferol 4'-O-methyl ether

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20mg USD 130  USD130 In stock
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Biological Activity

Kaempferide is an O-methylated flavonol also found in kaempferia galanga. Kaempferide has antiviral activity.

Chemical Information
Molecular Weight 300.26
Formula C16H12O6
CAS Number 491-54-3
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Xiaoli Ma, et al. Kaempferide enhances antioxidant capacity to promote osteogenesis through FoxO1/β-catenin signaling pathway

[2] Fangfang Tie, et al. Kaempferol and Kaempferide Attenuate Oleic Acid-Induced Lipid Accumulation and Oxidative Stress in HepG2 Cells

[3] Heng Tang, et al. Kaempferide improves oxidative stress and inflammation by inhibiting the TLR4/IκBα/NF-κB pathway in obese mice

[4] Heng Tang, et al. Kaempferide improves glycolipid metabolism disorder by activating PPARγ in high-fat-diet-fed mice

[5] Hiroaki Eguchi, et al. Kaempferide Enhances Chemosensitivity of Human Lung Adenocarcinoma A549 Cells Mediated by the Decrease in Phosphorylation of Akt and Claudin-2 Expression

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Keywords: Kaempferide, Kaempferol 4'-O-methyl ether supplier, Estrogen Receptor, inhibitors, activators

 
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