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Juncuenin B

Cat. No. M17309
Juncuenin B Structure
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Biological Activity

Juncuenin B

Chemical Information
CAS Number 1161681-20-4
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Csaba Bs, et al. J Nat Prod. Oxidized Juncuenin B Analogues with Increased Antiproliferative Activity on Human Adherent Cell Lines: Semisynthesis and Biological Evaluation

[2] Lu Sun, et al. Fitoterapia. Anxiolytic effect of a novel 9,10-dihydrophenanthrene, juncuenin H, is associated with metabolic changes in cortical serotonin/dopamine levels in mice

[3] Lu Sun, et al. Zhongguo Zhong Yao Za Zhi. [Phenanthrenes from aerial part of Juncus setchuensis with anxiolyticactivity]

[4] Barbara Tth, et al. Fitoterapia. Screening of Luzula species native to the Carpathian Basin for anti-inflammatory activity and bioactivity-guided isolation of compounds from Luzula luzuloides (Lam.) Dandy & Wilmott

[5] Kan'ichiro Ishiuchi, et al. J Nat Med. Chemical constituents isolated from Juncus effusus induce cytotoxicity in HT22 cells

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