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Isradipine

Cat. No. M5717

Isradipine Structure

Synonym: PN 200-110

Size Price Availability Quantity
10mg USD 50 In stock
50mg USD 190 In stock
100mg USD 320 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Isradipine is a potent and selective L-type voltage-gated calcium channel blocker, used to treat high blood pressure.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 371.39
Formula C19H21N3O5
CAS Number 75695-93-1
Purity >99%
Solubility 74 mg/mL in DMSO
Storage at -20°C
References

Amorphous isradipine nanosuspension by the sonoprecipitation method.
Tran TT, et al. Int J Pharm. 2014 Oct 20;474(1-2):146-50. PMID: 25138256.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Isradipine, PN 200-110 supplier, Calcium Channel, inhibitors

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