Isoquercitrin is a rare, natural ingredient with several biological activities that is a key precursor for the synthesis of enzymatically modified isoquercitrin (EMIQ).Isoquercitrin attenuated FFA induced lipid overload and ROS within hepatocytes. Further, Isoquercitrin reversed FFA induced increase in intracellular TG SOD and MDA. It was shown that antioxidative activity of Isoquercitrin correlates with its lipid lowering potentials. Isoquercitrin reversed major proinflammatory cytokines and oxidative stress in FFA/LPS induced coculture model.Isoquercitrin inhibits human pancreatic cancer progression in vivo and in vitro and that its molecular mechanism may be closely related to opioid receptors and to the activation of the mitogen-activated protein kinase (MAPK) signalling pathway.Isoquercitrin exerts its fungicidal effect by disturbing the membrane of cells.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
An effective biphase system accelerates hesperidinase-catalyzed conversion of rutin to isoquercitrin.
Wang J, et al. Sci Rep. 2015 Mar 3;5:8682. PMID: 25731802.
Fungicidal effect of isoquercitrin via inducing membrane disturbance.
Yun J, et al. Biochim Biophys Acta. 2015 Feb;1848(2):695-701. PMID: 25445674.
Isoquercitrin inhibits the progression of pancreatic cancer in vivo and in vitro by regulating opioid receptors and the mitogen-activated protein kinase signalling pathway.
Chen Q, et al. Oncol Rep. 2015 Feb;33(2):840-8. PMID: 25434366.
Reduced oxidative stress contributes to the lipid lowering effects of isoquercitrin in free fatty acids induced hepatocytes.
Hassan W, et al. Oxid Med Cell Longev. 2014;2014:313602. PMID: 25404990.
Isoquercitrin suppresses colon cancer cell growth in vitro by targeting the Wnt/β-catenin signaling pathway.
Amado NG, et al. J Biol Chem. 2014 Dec 19;289(51):35456-67. PMID: 25359775.
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