|M5279||NCB-0846||NCB-0846 is a novel, orally small-molecule Wnt inhibitor that inhibits TNIK (TRAF2 and NCK-Interacting Kinase) with an IC50 value of 21 nM.|
|M5261||CP21R7||CP21R7, also known CP21, is a potent and selective GSK-3β inhibitor that can potently activate canonical Wnt signalling.|
|M4866||LF3||LF3 is a specific inhibitor of canonical Wnt signaling by disrupting the interaction between β-catenin and TCF4 with an IC50 less than 2 μM.|
|M4003||Isoquercitrin||isoquercitrin is an inhibitor of Wnt/β-catenin and should be further investigated as a potential novel anti-tumoral agent.|
|M3886||WAY-262611||WAY-262611 is a Wnt pathway agonist acting via inhibition of Dkk1 with no GSK-3β inhibition and the TCF-Luciferase EC50=0.63µM.|
|M3131||Wnt-C59||Wnt-C59 (C59) is a PORCN inhibitor for Wnt3A-mediated activation of a multimerized TCF-binding site driving luciferase with IC50 of 74 pM.|
|M2812||LGK-974||LGK-974 is a potent and specific PORCN inhibitor, and inhibits Wnt signaling with IC50 of 0.4 nM.|
|M2800||KY02111||KY02111 promotes differentiation of hPSCs to cardiomyocytes by inhibiting Wnt signaling, may act downstream of APC and GSK3β.|
|M2782||IWR-1-endo||IWR-1 (endo-IWR 1) is a Wnt pathway inhibitor with IC50 of 180 nM, induces Axin2 protein levels and promotes β-catenin phosphorylation by stabilizing Axin-scaffolded destruction complexes.|
|M2781||IWP-L6||IWP-L6 is a highly potent Porcn inhibitor with EC50 of 0.5 nM.|
|M2237||IWP-2||IWP-2 is an inhibitor of Wnt production that impairs Wnt pathway activity in vitro with an IC50 value of 27 nM.|
|M2008||ICG-001||ICG-001 is a novel small molecule inhibitor of TCF/beta-catenin-mediated transcription.|
|M1796||XAV939||XAV939 is a potent, cell-permeable small molecule inhibitor of the Wnt/β-catenin pathway to TNKS1 and TNKS2 with IC50 values of 11 and 4 nM respectively.|
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