Iseganan is a protein integrin as well as an anti-microbial peptide that is active against both Gram-positive and Gram-negative bacteria as well as fungi, and kills bacteria and fungi by attaching to and disrupting the integrity of lipid cell membranes. It can be used in studies related to oral mucositis.
| Molecular Weight | 1900.29 |
| Formula | C78H126N30O18S4 |
| CAS Number | 257277-05-7 |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[3] Francis J Giles, et al. Expert Opin Investig Drugs. Iseganan HCl: a novel antimicrobial agent
[4] Jeffrey H Toney. Curr Opin Investig Drugs. Iseganan (IntraBiotics pharmaceuticals)
[5] No authors listed. Drugs R D. Iseganan. IB 367, protegrin IB 367
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