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Isavuconazole

Cat. No. M6172
Isavuconazole Structure
Synonym:

BAL-4815; RO-0094815

Size Price Availability Quantity
1mg USD 200 In stock
5mg USD 880 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Isavuconazole shows good activity against all Candida spp., with active MIC50 of 0.004 mg/L. The MIC50s/MIC90s range from 0.002/0.004 mg/L for C. albicans to 0.25/0.5 mg/L for C. glabrata. Isavuconazole has potent in vitro activity against most common Aspergillus species, Purpureocillium lilacinum, and Scedosporium apiospermum. Isavuconazole shows potent activity against molds, yeasts, and dimorphic fungi. Rhizopus isolates have MIC values to isavuconazole as low as 0.12 µg/mL with others as high as 32 µg/mL. Isavuconazole shows potent activity against molds, yeasts, and dimorphic fungi. Rhizopus isolates have MIC values to isavuconazole as low as 0.12 µg/mL with others as high as 32 µg/mL.

Protocol
Cell Experiment
Cell lines L‐type Ca2+ channels
Preparation method The in vitro effects of isavuconazole on a panel of human cardiac Ca2+, K+, and Na+ channels were assessed by recording transmembrane currents in cultured cells stably transfected with genes encoding each channel.
Concentrations 1, 3, 10, or 30 μM
Incubation time 24‐h
Animal Experiment
Animal models
Formulation
Dosages
Administration
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 437.47
Formula C22H17F2N5OS
CAS Number 241479-67-4
Purity >99%
Solubility 10 mM in DMSO
Storage at -20°C
References

QT Interval Shortening With Isavuconazole: In Vitro and In Vivo Effects on Cardiac Repolarization.
Keirns J, et al. Clin Pharmacol Ther. 2017 Jun;101(6):782-790. PMID: 28074556.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Isavuconazole, BAL-4815; RO-0094815 supplier, inhibitors

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