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Iridin

Cat. No. M16828
Iridin Structure
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Biological Activity

Iridin

Chemical Information
CAS Number 491-74-7
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Tao Hu, et al. J Chromatogr B Analyt Technol Biomed Life Sci. Metabolite identification of iridin in rats by using UHPLC-MS/MS and pharmacokinetic study of its metabolite irigenin

[2] Pritam-Bhagwan Bhosale, et al. Molecules. Iridin Induces G2/M Phase Cell Cycle Arrest and Extrinsic Apoptotic Cell Death through PI3K/AKT Signaling Pathway in AGS Gastric Cancer Cells

[3] Ya-Wen Yang, et al. Zhongguo Zhong Yao Za Zhi. [Effect of different drying methods on drying characteristics, appearance and active components of Belamcandae Rhizoma]

[4] Zhen-Hua Ying, et al. J Inflamm Res. Iridin Prevented Against Lipopolysaccharide-Induced Inflammatory Responses of Macrophages via Inactivation of PKM2-Mediated Glycolytic Pathways

[5] Rabia Nabi, et al. Arch Biochem Biophys. A biochemical & biophysical study on in-vitro anti-glycating potential of iridin against d-Ribose modified BSA

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