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Indole-3-carboxylic acid

Cat. No. M16012
Indole-3-carboxylic acid Structure
Synonym:

I3CA

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Biological Activity

Indole-3-carboxylic acid

Chemical Information
Molecular Weight 161.16
Formula C9H7NO2
CAS Number 771-50-6
Form Solid
Solubility (25°C) 95% Ethanol 50 mg/ml
Storage 2-8°C
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Yawei Que, et al. Front Cell Infect Microbiol. Indole-3-Carboxylic Acid From the Endophytic Fungus Lasiodiplodia pseudotheobromae LPS-1 as a Synergist Enhancing the Antagonism of Jasmonic Acid Against Blumeria graminis on Wheat

[2] Melissa M Cadelis, et al. ChemMedChem. Spermine Derivatives of Indole-3-carboxylic Acid, Indole-3-acetic Acid and Indole-3-acrylic Acid as Gram-Negative Antibiotic Adjuvants

[3] Vida Časaitė, et al. Microbiologyopen. Engineering of a chromogenic enzyme screening system based on an auxiliary indole-3-carboxylic acid monooxygenase

[4] Tnia M T Carvalho, et al. J Phys Chem A. Energetic Effect of the Carboxylic Acid Functional Group in Indole Derivatives

[5] Christoph Bttcher, et al. Plant Physiol. The Biosynthetic Pathway of Indole-3-Carbaldehyde and Indole-3-Carboxylic Acid Derivatives in Arabidopsis

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