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Indirubin

Cat. No. M2184
Indirubin Structure
Size Price Availability Quantity
10mg USD 95 In stock
50mg USD 330 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Indirubin is a cyclin-dependent kinase inhibitor which functions by competing with ATP for binding to the catalytic subunit. Indirubin is used in traditional Chinese medicine for anti-inflammatory, anti-tumor, and neuroprotective effects. Indirubin inhibits glycogen synthase kinase-3 (IC50 = 2.5 μM) and cyclin-dependent kinases 1 and 5 (IC50 = 10 μM for both isoforms). Indirubin also inhibits CDK1/5 with IC50 of 10 μM and 5.5 μM. Indirubin exhibits antiproliferative activity leading to G2/M arrest in many cell lines and G1/S arrest in Jurkat cells. Indirubin induces cell cycle arrest and inhibits cell proliferation.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 262.26
Formula C16H10N2O2
CAS Number 479-41-4
Purity >99%
Solubility DMSO 50 mg/mL
Storage at -20°C
References

Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors?
Leclerc S, et al. J Biol Chem. 2001 Jan 5;276(1):251-60. PMID: 11013232.

Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases.
Hoessel R, et al. Nat Cell Biol. 1999 May;1(1):60-7. PMID: 10559866.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Indirubin supplier, GSK-3, inhibitors

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