IL-17 modulator 1 is an orally active, highly efficacious small molecule IL-17 modulator. IL-17 modulator 1 can be used for the research of preventing, researching or ameliorating a variety of diseases including psoriasis, ankylosing spondylitis and psoriatic arthritis.
| Molecular Weight | 584.6 |
| Formula | C28H37N6O6P |
| CAS Number | 2446803-85-4 |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[2] Donggi Paik, et al. Nature. Human gut bacteria produce ΤΗ17-modulating bile acid metabolites
[3] Ritesh Kumar, et al. Trends Immunol. RORγt protein modifications and IL-17-mediated inflammation
[5] Eric V Dang, et al. Cell. Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1
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