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IKK-16

Cat. No. M2768

IKK-16  Structure
Size Price Availability Quantity
10mg USD 140 In stock
50mg USD 540 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

IKK 16 is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 483.63
Formula C28H29N5OS
CAS Number 873225-46-8
Purity >99%
Solubility DMSO 80 mg/mL
Storage at -20°C
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LY2409881 is a novel selective inhibitor of IKK2 with IC50 of 30 nM; IC50 for IKK1 and other common kinases is at least one log higher.

PS-1145

PS-1145 is a specific IKK inhibitor with IC50 of 88 nM.

Bardoxolone

Bardoxolone is an IKK inhibitor, showing potent proapoptotic and anti-inflammatory activities; Also a potent Nrf2 activator and nuclear factor-κB (NF-κB) inhibitor.

Amlexanox

Amlexanox is a specific inhibitor of IKKε and TBK1.

PHA-408

PHA-408 is a highly selective and ATP-competitive IKK-2 inhibitor with IC50 of 40 nM.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: IKK-16 supplier, IκB/IKK, inhibitors

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