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Idalopirdine hydrochloride

Cat. No. M9025
Idalopirdine hydrochloride Structure

Lu AE58054 HCl

Size Price Availability Quantity
5mg USD 265 In stock
10mg USD 360 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Idalopirdine hydrochloride displayed high affinity to the human 5-HT(6) receptor (5-HT(6)R) with a Ki of 0.83 nm. In vivo, orally administered Idalopirdine hcl potently inhibited striatal in-vivo binding of the 5-HT(6) antagonist radioligand [(3)H]Lu AE60157, with an ED(50) of 2.7 mg/kg.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 434.83
Formula C20H20ClF5N2O
CAS Number 467458-02-2
Purity >99%
Solubility DMSO: ≥ 20 mg/mL
Storage at -20°C

Characterization of [³H]Lu AE60157 ([³H]8-(4-methylpiperazin-1-yl)-3-phenylsulfonylquinoline) binding to 5-hydroxytryptamine₆ (5-HT₆) receptors in vivo.
Witten L, et al. Eur J Pharmacol. 2012 Feb 15;676(1-3):6-11. PMID: 22155399.

Lu AE58054, a 5-HT6 antagonist, reverses cognitive impairment induced by subchronic phencyclidine in a novel object recognition test in rats.
Arnt J, et al. Int J Neuropsychopharmacol. 2010 Sep;13(8):1021-33. PMID: 20569520.

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Keywords: Idalopirdine hydrochloride, Lu AE58054 HCl supplier, 5-HT Receptor, inhibitors

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