Free shipping on all orders over $ 500


Cat. No. M2591
Icilin Structure

AG 3-5

Size Price Availability Quantity
10mM*1mL In DMSO USD 80 In stock
10mg USD 70 In stock
50mg USD 260 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Icilin is a synthetic super-agonist of the transient receptor potential M8 (TRPM8) ion channel.icilin, a super-cooling agent, down-regulated the expression of cell cycle signature genes and caused G1 arrest in PC-3 prostate cancer cells. Icilin Induces currents in CMR1-expressing HEK 293 cells (EC50 = 0.36 μM) more potently than menthol or low temperatures. icilin affected cell cycle-related transcriptional modules and identified E2F1 transcription factor as a target master regulator of icilin. icilin reduced the activity and expression levels of E2F1.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 311.29
Formula C16H13N3O4
CAS Number 36945-98-9
Purity >98%
Solubility DMSO 15 mg/ml
Storage at -20°C

Icilin inhibits E2F1-mediated cell cycle regulatory programs in prostate cancer.
Lee S,et al. Biochem Biophys Res Commun. 2013 Nov 29;441(4):1005-10. PMID: 24239550.

Related TRP Channel Products

HC-067047 is a potent, selective inhibitor of hTRPV4.


ML SA1 is a activator of TRPML channels.


EIPA is a inhibits TRPP3-mediated currents; also inhibits the Na +/H + exchanger (NHE).


BCTC is a tRPV1 antagonist.


Camphor is a waxy, flammable, white or transparent solid with a strong aroma, often used to relieve pain, reduce itching and treat fungal infections. It can activate TRPV1 and TRPV3.

Abmole Inhibitor Catalog 2017

Keywords: Icilin, AG 3-5 supplier, TRP Channel, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.