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IACS-10759

Cat. No. M9412
IACS-10759 Structure
Size Price Availability
5mg USD 147 4-7 Days
10mg USD 227 4-7 Days
25mg USD 457 4-7 Days
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

IACS-10759 is a potent inhibitor of complex I of oxidative phosphorylation (OXPHOS). IACS-10759 is orally bioavailable with excellent physicochemical properties in preclinical species and achieves significant in vivo efficacy with daily oral dosing of 10-25 mg/kg.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 562.56
Formula C25H25F3N6O4S
CAS Number 1570496-34-2
Purity >99%
Solubility DMSO ≥ 30 mg/mL
Storage at -20°C
References

IACS-10759: A novel OXPHOS inhibitor which selectively kill tumors with metabolic vulnerabilities
Marina P, et al. AACR; Cancer Res. 2015 Aug;Volume 75, Issue 15 Supplement, pp. 4380.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: IACS-10759 supplier, inhibitors

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