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Hydrocortisone

Cat. No. M3451
Hydrocortisone Structure
Synonym:

Cortisol

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
10mM*1mL in DMSO USD 36  USD40 In stock
100mg USD 27  USD30 In stock
500mg USD 43.2  USD48 In stock
1g USD 54  USD60 In stock
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Quality Control
Biological Activity

Hydrocortisone is a steroid hormone or glucocorticoid produced by the adrenal gland. It is released in response to stress, and to a low level of blood glucocorticoids. Its primary functions are to increase blood sugar through gluconeogenesis, suppress the immune system, and aid in fat, protein, and carbohydrate metabolism. It also decreases bone formation. Various synthetic forms of cortisol are used to treat a variety of different illnesses.

Product Citations
Customer Product Validations & Biological Datas
Source BMC Ophthalmology. 2020 Nov. Figure 1. hydrocortisone (Abmole Bioscience, USA)
Method proliferation ability assay
Cell Lines HMEC-1 cell
Concentrations 1μg/ml
Incubation Time -
Results Under hyperoxia condition, the proliferation of HMEC-1 is inhibited, 5-40 µM heme promoted the proliferation ability of HMEC-1, more than or equal to 80 µM showed inhibition
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 362.46
Formula C21H30O5
CAS Number 50-23-7
Purity 99.72%
Solubility DMSO 33 mg/mL
Storage -20°C, protect from light, sealed
References

Developmental changes in the in vitro activated regenerative activity of primitive mammary epithelial cells
Maisam Makarem, et al. PLoS Biol. 2013;11(8):e1001630. PMID: 23966837.

New role for the protein tyrosine phosphatase DEP-1 in Akt activation and endothelial cell survival
Catherine Chabot, et al. Mol Cell Biol. 2009 Jan;29(1):241-53. PMID: 18936167.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Hydrocortisone, Cortisol supplier, GCR, inhibitors

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