Hydrocortisone is a steroid hormone or glucocorticoid produced by the adrenal gland. It is released in response to stress, and to a low level of blood glucocorticoids. Its primary functions are to increase blood sugar through gluconeogenesis, suppress the immune system, and aid in fat, protein, and carbohydrate metabolism. It also decreases bone formation. Various synthetic forms of cortisol are used to treat a variety of different illnesses.
BMC Ophthalmol. 2021 Feb 25;21(1):104.
Heme relieves the inhibition of proliferation, migration and angiogenesis of HMEC-1 under hyperoxia by inhibiting BACH1
Hydrocortisone purchased from AbMole
|Source||BMC Ophthalmology. 2020 Nov. Figure 1. hydrocortisone (Abmole Bioscience, USA)|
|Method||proliferation ability assay|
|Cell Lines||HMEC-1 cell|
|Results||Under hyperoxia condition, the proliferation of HMEC-1 is inhibited, 5-40 µM heme promoted the proliferation ability of HMEC-1, more than or equal to 80 µM showed inhibition|
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
|Solubility||DMSO 33 mg/mL|
|Storage||-20°C, protect from light, sealed|
Developmental changes in the in vitro activated regenerative activity of primitive mammary epithelial cells
Maisam Makarem, et al. PLoS Biol. 2013;11(8):e1001630. PMID: 23966837.
New role for the protein tyrosine phosphatase DEP-1 in Akt activation and endothelial cell survival
Catherine Chabot, et al. Mol Cell Biol. 2009 Jan;29(1):241-53. PMID: 18936167.
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