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Human β-defensin-3

Cat. No. M40760
Human β-defensin-3 Structure
Synonym:

hBD-3; HβD-3

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Biological Activity

Human β-defensin-3 is an antimicrobial peptide produced by epithelial cells that reduces inflammatory cytokine responses, as well as inhibits microbial growth, and has immunomodulatory activity with IC90 values ranging from 6-25 μg/ml.

Chemical Information
Molecular Weight 5155.17
Formula C216H371N75O59S6
CAS Number 221230-01-9
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Ge Peng et al. J Clin Invest. Human β-defensin-3 attenuates atopic dermatitis-like inflammation through autophagy activation and the aryl hydrocarbon receptor signaling pathway

[2] Soumya Panigrahi et al. Front Mol Biosci. Human β-Defensin-3 is Associated With Platelet-Derived Extracellular Vesicles and is a Potential Contributor to Endothelial Dysfunction

[3] Miho Takahashi et al. Front Immunol. The Antimicrobial Peptide Human β-Defensin-3 Accelerates Wound Healing by Promoting Angiogenesis, Cell Migration, and Proliferation Through the FGFR/JAK2/STAT3 Signaling Pathway

[4] Noura Al Mansour et al. SAGE Open Med. Dysregulation of human beta-defensin-3 expression in the peripheral blood of patients with sepsis

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Keywords: Human β-defensin-3, hBD-3; HβD-3 supplier, Anti-infection, inhibitors, activators

 
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