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Hirsutanonol

Cat. No. M17277
Hirsutanonol Structure
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Biological Activity

Hirsutanonol (Oil)

Chemical Information
CAS Number 41137-86-4
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Seo-Yeon Seonu, et al. Molecules. Alnus sibirica Compounds Exhibiting Anti-Proliferative, Apoptosis-Inducing, and GSTP1 Demethylating Effects on Prostate Cancer Cells

[2] Da-Wei Zhang, et al. Int J Antimicrob Agents. Natural-product-library-based screening for discovery of capsid C-terminal domain targeted HIV-1 inhibitors

[3] Hye Soo Wang, et al. Molecules. Inhibitory Effects on NO Production and DPPH Radicals and NBT Superoxide Activities of Diarylheptanoid Isolated from Enzymatically Hydrolyzed Ehthanolic Extract of Alnus sibirica

[4] Deepti Yadav, et al. J Chromatogr Sci. Simultaneous quantification of diarylheptanoids in Alnus nepalensis using a validated HPTLC method

[5] Miroslav Novaković, et al. Planta Med. Diarylheptanoids from Alnus glutinosa bark and their chemoprotective effect on human lymphocytes DNA

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