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Higenamine hydrochloride

Cat. No. M10994
Higenamine hydrochloride Structure
Synonym:

Norcoclaurine hydrochloride

Size Price Availability Quantity
100mg USD 48  USD48 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Higenamine hydrochloride (Norcoclaurine hydrochloride) is a beta2-AR agonist that is a key ingredient in the Aconitum of Chinese medicine used in heart failure-related studies. Higenamine hydrochloride (Norcoclaurine hydrochloride) has an anti-apoptotic effect.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 307.77202
Formula C16H18ClNO3
CAS Number 11041-94-4
Purity >99%
Solubility DMSO ≥ 60 mg/mL
Storage 4°C , protect from light , dry , sealed
References

[1] Xiaona Yang, et al. Dose Response. Neuroprotective Effects of Higenamine Against the Alzheimer's Disease Via Amelioration of Cognitive Impairment, A β Burden, Apoptosis and Regulation of Akt/GSK3β Signaling Pathway

[2] Meichen Liu, et al. J Chromatogr B Analyt Technol Biomed Life Sci. Synergistic effect of Aconiti Lateralis Radix Praeparata water-soluble alkaloids and Ginseng Radix et Rhizoma total ginsenosides compatibility on acute heart failure rats

[3] Nana Zhang, et al. Phytother Res. Identification of higenamine as a novel α 1 -adrenergic receptor antagonist

[4] Sheng Feng, et al. J Chromatogr B Analyt Technol Biomed Life Sci. Determination of higenamine in human plasma and urine using liquid chromatography coupled to positive electrospray ionization tandem mass spectrometry

[5] C F Lo, et al. J Chromatogr B Biomed Appl. Determination of higenamine in plasma and urine by high-performance liquid chromatography with electrochemical detection

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