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GW2580

Cat. No. M2743
GW2580 Structure
Synonym:

SC-203877

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
10mg USD 45  USD45 In stock
50mg USD 90  USD90 In stock
100mg USD 120  USD120 In stock
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Quality Control & Documentation
Biological Activity

GW2580 is a selective CSF-1R inhibitor for c-FMS with IC50 of 30 nM, 150- to 500-fold selective compared to b-Raf, CDK4, c-KIT, c-SRC, EGFR, ERBB2/4, ERK2, FLT-3, GSK3, ITK, JAK2 etc.

Product Citations
Chemical Information
Molecular Weight 366.41
Formula C20H22N4O3
CAS Number 870483-87-7
Solubility (25°C) DMSO 28 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] James G Conway, et al. Proc Natl Acad Sci U S A. Inhibition of colony-stimulating-factor-1 signaling in vivo with the orally bioavailable cFMS kinase inhibitor GW2580

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  Catalog
Abmole Inhibitor Catalog




Keywords: GW2580, SC-203877 supplier, CSF-1R (c-Fms), inhibitors, activators


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