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GSK726701A

Cat. No. M10827
GSK726701A  Structure
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

GSK726701A is a partial agonist of prostaglandin E2 receptor 4 (EP4),pEC50is 7.4.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 423.43
Formula C24H22FNO5
CAS Number 945721-87-9
Purity >98%
Solubility DMSO ≥ 20 mg/mL
Storage at -20°C
References

[1] Mark P Healy, et al. Bioorg Med Chem Lett. Discovery of {4-[4,9-bis(ethyloxy)-1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl]-2-fluorophenyl}acetic acid (GSK726701A), a novel EP 4 receptor partial agonist for the treatment of pain

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Keywords: GSK726701A supplier, Prostaglandin Receptor, inhibitors

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