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Grifolin

Cat. No. M17353
Grifolin Structure
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Biological Activity

Grifolin

Chemical Information
CAS Number 6903-07-7
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Liguo Wang, et al. RSC Adv. Design and synthesis of water-soluble grifolin prodrugs for DNA methyltransferase 1 (DNMT1) down-regulation

[2] Abdelhakim Bouyahya, et al. Molecules. Pharmacological Effects of Grifolin: Focusing on Anticancer Mechanisms

[3] Nicholas G Jentsch, et al. J Nat Prod. Efficient Synthesis of Cannabigerol, Grifolin, and Piperogalin via Alumina-Promoted Allylation

[4] Almas Yaqoob, et al. PLoS One. Grifolin, neogrifolin and confluentin from the terricolous polypore Albatrellus flettii suppress KRAS expression in human colon cancer cells

[5] Xiangjian Luo, et al. Oncotarget. Grifolin directly targets ERK1/2 to epigenetically suppress cancer cell metastasis

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