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GR 159897 is a a potent, selective, non-peptide, orally active neurokinin NK2 receptor antagonist. Competes for binding of [3H]GR100679 to hNK2-transfected CHO cells with a pKi of 9.5. Inhibits NK2 receptor-mediated contraction of guinea pig trachea with a pA2 of 8.7. Anxiolytic in vivo.
| Molecular Weight | 414.54 |
| Formula | C23H27FN2O2S |
| CAS Number | 158848-32-9 |
| Solubility (25°C) | DMSO 20.73 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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