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Glucan

Cat. No. M22406
Glucan Structure
Size Price Availability Quantity
100mg USD 80  USD80 In stock
500mg USD 180  USD180 In stock
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Quality Control & Documentation
Biological Activity

Glucan

Chemical Information
CAS Number 9012-72-0
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Robert Pylkknen, et al. Nanoscale. β-1,3-Glucan synthesis, novel supramolecular self-assembly, characterization and application

[2] Gregory S Bulmer, et al. Carbohydr Res. Recent advances in enzymatic synthesis of β-glucan and cellulose

[3] Lijuan Wu, et al. Int J Biol Macromol. Antitumor effect of soluble β-glucan as an immune stimulant

[4] Johannes Wagener, et al. Curr Top Microbiol Immunol. α- and β-1,3-Glucan Synthesis and Remodeling

[5] Eiji Suzuki, et al. Cell Mol Life Sci. Distribution of glucan-branching enzymes among prokaryotes

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