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GLPG0974

Cat. No. M10096

All AbMole products are for research use only, cannot be used for human consumption.

GLPG0974 Structure
Synonym:

GLPG-0974

Size Price Availability Quantity
1mg USD 51  USD51 In stock
5mg USD 139  USD139 In stock
10mg USD 229  USD229 In stock
25mg USD 436  USD436 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?
Quality Control & Documentation
  • Purity: >98%, ee.: 98.57%
  • COA
  • MSDS
Biological Activity

GLPG0974 is a potent and selective FFA2 (also called GPR43) antagonist with IC50 of 9 nM. GLPG0974 inhibits acetate-induced neutrophil migration strongly in vitro and demonstrated ability to inhibit a neutrophil-based pharmacodynamic (PD) marker, CD11b activation-specific epitope [AE], in a human whole blood assay.

Product Citations
Chemical Information
Molecular Weight 484.99
Formula C25H25ClN2O4S
CAS Number 1391076-61-1
Solubility (25°C) DMSO ≥ 100 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] John Jackson Yang, et al. Microorganisms. Mouse Abdominal Fat Depots Reduced by Butyric Acid-Producing Leuconostoc mesenteroides

[2] Meng Li, et al. Front Pharmacol. The Anti-inflammatory Effects of Short Chain Fatty Acids on Lipopolysaccharide- or Tumor Necrosis Factor α-Stimulated Endothelial Cells via Activation of GPR41/43 and Inhibition of HDACs

[3] Yasutada Akiba, et al. Am J Physiol Gastrointest Liver Physiol. FFA2 activation combined with ulcerogenic COX inhibition induces duodenal mucosal injury via the 5-HT pathway in rats

[4] Florence Namour, et al. Br J Clin Pharmacol. Safety, pharmacokinetics and pharmacodynamics of GLPG0974, a potent and selective FFA2 antagonist, in healthy male subjects

[5] Mathieu Pizzonero, et al. J Med Chem. Discovery and optimization of an azetidine chemical series as a free fatty acid receptor 2 (FFA2) antagonist: from hit to clinic

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Keywords: GLPG0974, GLPG-0974 supplier, FAS, inhibitors, activators

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