Free shipping on all orders over $ 500
GLPG0974 is a potent and selective FFA2 (also called GPR43) antagonist with IC50 of 9 nM. GLPG0974 inhibits acetate-induced neutrophil migration strongly in vitro and demonstrated ability to inhibit a neutrophil-based pharmacodynamic (PD) marker, CD11b activation-specific epitope [AE], in a human whole blood assay.
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Molecular Weight | 484.99 |
| Formula | C25H25ClN2O4S |
| CAS Number | 1391076-61-1 |
| Purity | >98% |
| Solubility | |
| Storage | at -20°C |
| Related FAS Products |
|---|
| TVB-3664
TVB-3664 is a FASN inhibitor which significantly reduces tubulin palmitoylation and mRNA expression. |
| Triheptanoin
Triheptanoin (IND106011; UX007) is a fatty acid metabolic modulator. |
| AP1903 (Rimiducid)
Rimiducid (AP1903) is a lipid-permeable tacrolimus analogue acts by cross-linking the FKBP domains. *The compound is unstable in solutions, freshly prepared is recommended |
| Fatostatin
Fatostatin A is a cell permeable inhibitor of SREBP activation, it inhibits cancer cell proliferation by affecting mitotic microtubule spindle assembly and cell division. |
| C75 trans
C75 trans is an enantiomer of C75, which is a synthetic fatty-acid synthase (FASN) inhibitor. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.
