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GLPG0634 analogue

Cat. No. M4912
GLPG0634 analogue Structure
Size Price Availability Quantity
10mM*1mL In DMSO USD 210 In stock
2mg USD 125 In stock
5mg USD 225 In stock
10mg USD 400 In stock
50mg USD 1200 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

GLPG0634 inhibits IL-2- and IL-4-induced JAK1/JAK3/γc signaling and IFN-αB2-induced JAK1/TYK2 type II receptor signaling with IC50 ranged from 150 to 760 nM. GLPG0634 shows higher selectivity for JAK/STAT signaling involving JAK1 than JAK2 kinase in a cellular context. Besides, GLPG0634 also inhibits the differentiation of Th1, Th2, and Th17 cells.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 410.43
Formula C23H18N6O2
CAS Number 1206101-20-3
Purity >98%
Solubility DMSO 0.1 mg/mL;Water <1 mg/mL
Storage at -20°C
References

Preclinical characterization of GLPG0634, a selective inhibitor of JAK1, for the treatment of inflammatory diseases.
Van Rompaey L,et.al. J Immunol. 2013 Oct 1;191(7). PMID: 24006460.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: GLPG0634 analogue supplier, JAK, inhibitors

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