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GLPG0187

Cat. No. M5241
GLPG0187  Structure
Size Price Availability Quantity
10mM*1mL In DMSO USD 480 In stock
1mg USD 133 In stock
5mg USD 366 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

GLPG0187 treatment significantly (p < 0.05) reduced PC3 cell number within the metatarsal in vivo and reduced migration (p < 0.05) and proliferation (p < 0.05) but not cell viability in vitro. This new model allows evaluation of the early events of tumour-cell homing and localisation to the bone microenvironment, in addition to determining responses to therapeutic interventions.

Customer Product Validations & Biological Datas
Source Int J Cancer (2015). Figure 3. GLPG0187
Method cell viability, proliferation, migration assay
Cell Lines PC3 cell
Concentrations 50 ng/ml
Incubation Time 96 hr
Results GLPG0187 significantly (p<0.05) reduced the number of tumour cells present in the implanted metatarsal from day 17 on ward
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 595.71
Formula C29H37N7O5S
CAS Number 1320346-97-1
Purity >98%
Solubility 10mM in DMSO
Storage at -20°C
References

Genetic depletion and pharmacological targeting of αv integrin in breast cancer cells impairs metastasis in zebrafish and mouse xenograft models.
Li Y, et al, Breast Cancer Res. 2015 Feb 25;17:28. PMID: 25849225.

Prostate cancer cells home to bone using a novel in vivo model: modulation by the integrin antagonist GLPG0187.
Reeves KJ, et al. Int J Cancer. 2015 Apr 1;136(7):1731-40. PMID: 25156971.

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  Catalog
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Keywords: GLPG0187 supplier, Integrin, inhibitors

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