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Genkwanin (Genkwanin) is an O-methylated flavonoid with anti-inflammatory activity. Genkwanin inhibits the LPS-induced production of NO in a concentration-dependent manner. iNOS only expresses in the present of external stimulus. Genkwanin could not significantly affect the activity of iNOS. The effect of Genkwanin on the production of proinflammatory cytokines is examined. Genkwanin suppresses the productions of TNF-a, IL-1b and IL-6 in LPS stimulated RAW264.7 macrophages in a concentration-dependent manner. Genkwanin significantly suppresses the AP-1 signaling pathway but has little effect on the NF-kB signaling pathway. It is indicated that Genkwanin suppresses the phosphorylation of p38 and JNK in a concentration-dependent manner, but little affects ERK1/2 phosphorylation.
| Molecular Weight | 284.26 |
| Formula | C16H12O5 |
| CAS Number | 437-64-9 |
| Solubility (25°C) | DMSO 30 mg/mL |
| Storage | 2-8°C, protect from light |
[3] Astghik Hakobyan, et al. Inhibition of African swine fever virus infection by genkwanin
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