Gallocyanine is a small molecule DKK1 inhibitor, which blocks DKK1 inhibitory activity on Wnt signaling. Gallocyanine is also used as nuclear dye in staining.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||Ethanol ≥ 15 mM|
|Storage||2-8°C, dry, protect from light, sealed|
The role of Wnt signaling in the development of Alzheimer s disease: a potential therapeutic target?
Wan W, et al. Biomed Res Int. 2014;2014:301575. PMID: 24883305.
Chemical and genetic evidence for the involvement of Wnt antagonist Dickkopf2 in regulation of glucose metabolism.
Li X, et al. Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11402-7. PMID: 22733757.
In vitro and in vivo neurotoxicity of prion protein oligomers.
Simoneau S, et al. PLoS Pathog. 2007 Aug 31;3(8):e125. PMID: 17784787.
|Related Wnt/beta-catenin Products|
Adavivint (SM04690) is a potent and specific inhibitor of canonical Wnt signaling with an EC50 of 19.5 nM for inhibiting the TCF/LEF reporter.
Berberine is an alkaloid in several plants with various biological functions, including insulin-sensitizing, anti-inflammatory, and anti-oxidant activity.
ETC-159 is a potent, selective and orally available PORCN inhibitor, which inhibits β-catenin reporter activity with an IC50 of 2.9 nM.
Salinomycin is a carboxylic polyether ionophore with antibiotic and anti-cancer properties.
JW 74 is a wnt pathway inhibitor, with an IC50 of 420 nM.
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