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Gabapentin

Cat. No. M3600
Gabapentin Structure
Size Price Availability Quantity
10mg USD 40  USD40 In stock
50mg USD 70  USD70 In stock
100mg USD 110  USD110 In stock
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Quality Control & Documentation
Biological Activity

Gabapentin (Neurontin) is a pharmaceutical agent, specifically a GABA analogue. Gabapentin (Neurontin) was originally developed for the treatment of epilepsy, and currently, gabapentin is widely used to relieve pain, especially neuropathic pain. Its therapeutic action on neuropathic pain is thought to involve voltage-gated N-type calcium ion channels. It is thought to bind to the α2δ subunit (1 and 2) of the voltage-dependent calcium channel in the central nervous system.

Chemical Information
Molecular Weight 171.24
Formula C9H17NO2
CAS Number 60142-96-3
Solubility (25°C) Water 30 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Stephanie Mathieson, et al. Pregabalin and gabapentin for pain

[2] Raymond F Anton, et al. Efficacy of Gabapentin for the Treatment of Alcohol Use Disorder in Patients With Alcohol Withdrawal Symptoms: A Randomized Clinical Trial

[3] E E Morrison, et al. Gabapentin and pregabalin: do the benefits outweigh the harms?

[4] Helen Senderovich, et al. Is there a role for combined use of gabapentin and pregabalin in pain control? Too good to be true?

[5] Rachel V Smith, et al. Gabapentin misuse, abuse and diversion: a systematic review

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