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Furprofen

Cat. No. M14043
Furprofen Structure
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Furprofen is an non-steroidal anti-inflammatory drug (NSAID) with analgesic properties. Furprofen acts via the inhibition of prostaglandin (PGE) synthesis. Furprofen can be treated orally for the relief of pain.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 244.24
Formula
CAS Number 66318-17-0
Purity >99%
Solubility Ethanol 90 mg/mL
DMSO 62.5 mg/mL
Storage at -20°C
References

[1] A Tartaglia, et al. Fast off-line FPSE-HPLC-PDA determination of six NSAIDs in saliva samples

[2] Vincenzo Ferrone, et al. Dispersive magnetic solid phase extraction exploiting magnetic graphene nanocomposite coupled with UHPLC-PDA for simultaneous determination of NSAIDs in human plasma and urine

[3] Marcello Locatelli, et al. Microextraction by packed sorbent and high performance liquid chromatography determination of seven non-steroidal anti-inflammatory drugs in human plasma and urine

[4] G Carlucci, et al. A high performance liquid chromatographic procedure for the simultaneous determination of norfloxacin and furprofen in rat plasma

[5] G Carlucci, et al. Quantitation of the enantiomers of furprofen in biological fluids by high-performance liquid chromatography

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Keywords: Furprofen supplier, Prostaglandin Receptor, inhibitors

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