FTBMT (TP-024) is a selective GPR52 agonist with an EC50 of 75 nM. FTBMT (TP-024) (0.1-10 μM) increases intracellular cAMP levels in CHO cells expressing human, mouse, or rat GPR52, with pEC50s of 7.03, 6.85, and 6.87, respectively.
FTBMT (TP-024) (3 or 10 mg/kg, 48 hours) improves recognition and spatial working memory in rats. FTBMT (TP-024) (3, 10, 30 mg/kg, 2 hours) stimulates neuronal activity in brain regions related to cognition.
| Molecular Weight | 392.35 |
| Formula | C19H16F4N4O |
| CAS Number | 1358575-02-6 |
| Solubility (25°C) | DMSO ≥ 40 mg/mL |
| Storage | 4°C, protect from light |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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| BigLEN(rat)
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| BigLEN(mouse)
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| Neuropeptide EI, rat
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