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FR198248

Cat. No. M41205
FR198248 Structure
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Biological Activity

FR198248 is an anti-influenza agent and peptide deformylase (PDF) inhibitor.

Chemical Information
Molecular Weight 198.17
Formula C9H10O5
CAS Number 197316-54-4
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Yun-Ju Kwon et al. Biosci Biotechnol Biochem. Isolation and identification of FR198248, a hydroxylated 1,3-dihydroisobenzofuran, from Aspergillus flavipes as an inhibitor of peptide deformylase

[2] Y Nishihara et al. J Antibiot (Tokyo). New anti-influenza agents, FR198248 and its derivatives. II. Characterization of FR198248, its related compounds and some derivatives

[3] Y Nishihara et al. J Antibiot (Tokyo). FR198248, a new anti-influenza agent isolated from Apsergillus terreus No 13830. I. Taxomony, fermentation, isolation, physico-chemical properties and biological activities

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Abmole Inhibitor Catalog




Keywords: FR198248 supplier, Anti-infection, inhibitors, activators

 
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