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Fluphenazine dihydrochloride

Cat. No. M5198
Fluphenazine dihydrochloride Structure
Synonym:

Fluphenazine 2HCl

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
10mM/1mL In DMSO USD 95 In stock
100mg USD 90 In stock
500mg USD 220 In stock
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Quality Control
Biological Activity

Fluphenazine dihydrochloride is a phenothiazine-class D1DR and D2DR inhibitor. Fluphenazine 2HCl also inhibits Histamine H1 Receptor.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 510.44
Formula C22H26F3N3OS.2HCl
CAS Number 146-56-5
Purity >99%
Solubility DMSO 100 mg/mL
Water 100 mg/mL
Storage at -20°C
References

A comparative study of the anticholinesterase activity of several antipsychotic agents.
Nasello AG, et al. Pharmacol Biochem Behav. 2003 Jul;75(4):895-901. PMID: 12957233.

Behavioral effects of withdrawal of fluphenazine after long-term treatment.
Trzeciak HI, et al. Arzneimittelforschung. 1976;26(9):1697-700. PMID: 1036703.

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Abmole Inhibitor Catalog 2017




Keywords: Fluphenazine dihydrochloride, Fluphenazine 2HCl supplier, Dopamine Receptor, inhibitors

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