Free shipping on all orders over $ 500

Fluphenazine dihydrochloride

Cat. No. M5198
Fluphenazine dihydrochloride Structure
Synonym:

Fluphenazine 2HCl

Size Price Availability Quantity
100mg USD 90 In stock
500mg USD 220 In stock
Bulk Inquiry?

Quality Control
Biological Activity

Fluphenazine dihydrochloride is a phenothiazine-class D1DR and D2DR inhibitor. Fluphenazine 2HCl also inhibits Histamine H1 Receptor.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 510.44
Formula C22H26F3N3OS.2HCl
CAS Number 146-56-5
Purity >99%
Solubility DMSO 100 mg/mL
Water 100 mg/mL
Storage at -20°C
References

A comparative study of the anticholinesterase activity of several antipsychotic agents.
Nasello AG, et al. Pharmacol Biochem Behav. 2003 Jul;75(4):895-901. PMID: 12957233.

Behavioral effects of withdrawal of fluphenazine after long-term treatment.
Trzeciak HI, et al. Arzneimittelforschung. 1976;26(9):1697-700. PMID: 1036703.

Related Dopamine Receptor Products
Sulpiride

Sulpiride is a dopamine D2-receptor antagonist. It has been used therapeutically as an antidepressant, antipsychotic, and as a digestive aid.

rac-Rotigotine (Hydrochloride)

rac-Rotigotine Hcl is a high potency and selectivity agonist for D-2 receptor with Ki of 0.69 nM.

Promazine HCl

Promazine (hydrochloride) is a D2 dopamine receptor antagonist, belongs to the phenothiazine class of antipsychotics, used to treat schizophrenia.

Prochlorperazine dimaleate salt

Prochlorperazine dimaleate is a dopamine (D2) receptor antagonist.

Pramipexole dihydrochloride

Pramipexole 2Hcl is a partial/full D2S, D2L, D3, D4 receptor agonist with a Ki of 3.9, 2.2, 0.5 and 5.1 nM for D2S, D2L, D3, D4 receptor, respectively.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Fluphenazine dihydrochloride, Fluphenazine 2HCl supplier, Dopamine Receptor, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2017 AbMole BioScience. All Rights Reserved.