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Flunarizine 2HCl

Cat. No. M5654

Flunarizine 2HCl Structure

Synonym: KW-3149, R14950

Size Price Availability Quantity
100mg USD 80 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Flunarizine 2HCl is a dihydrochloride salt form which is a calcium channel blocker with a Ki of 68 nM.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 477.42
Formula C26H26F2N2.2HCl
CAS Number 30484-77-6
Purity >99%
Solubility 5 mg/mL in DMSO
Storage at -20°C
References

Effect of KB-2796, a new diphenylpiperazine Ca2+ antagonist, on voltage-dependent Ca2+ currents and oxidative metabolism in dissociated mammalian CNS neurons.
Akaike N, et al. Brain Res. 1993 Aug 13;619(1-2):263-70. PMID: 8397053.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Flunarizine 2HCl, KW-3149, R14950 supplier, Calcium Channel, inhibitors

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