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Flumazenil

Cat. No. M5653
Flumazenil Structure
Synonym:

Ro 15-1788

Size Price Availability Quantity
50mg USD 120 In stock
100mg USD 180 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Flumazenil is a competitive GABAA receptor antagonist, used in the treatment of benzodiazepine overdoses.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 303.29
Formula C15H14FN3O3
CAS Number 78755-81-4
Purity >98%
Solubility 10 mM in DMSO
Storage at -20°C
References

Benzodiazepine dependence and its treatment with low dose flumazenil.
Hood SD, et al. Br J Clin Pharmacol. 2014 Feb;77(2):285-94. PMID: 23126253.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Flumazenil, Ro 15-1788 supplier, GABA Receptor, inhibitors

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