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Fluconazole

Cat. No. M5650
Fluconazole Structure
Synonym:

UK 49858

Size Price Availability Quantity
100mg USD 55  USD55 In stock
500mg USD 110  USD110 In stock
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Quality Control
Biological Activity

Fluconazole is a fungal lanosterol 14 alpha-demethylase inhibitor, which thereby prevents the formation of ergosterol,used in the treatment and prevention of superficial and systemic fungal infections.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 306.27
Formula C13H12F2N6O
CAS Number 86386-73-4
Purity 98.63%
Solubility 51 mg/mL in DMSO
Storage at -20°C
References

[1] van der Elst KC, et al. Clin Infect Dis. Insufficient fluconazole exposure in pediatric cancer patients and the need for therapeutic drug monitoring in critically ill children.

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Keywords: Fluconazole, UK 49858 supplier, Cytochrome P450 (e.g. CYP17), inhibitors

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