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Flosulide

Cat. No. M22331
Flosulide Structure
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Biological Activity

Flosulide

Chemical Information
Molecular Weight 353.34
Formula C16H13F2NO4S
CAS Number 80937-31-1
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] A Turull, et al. Inflammation. Acute effects of the anti-inflammatory cyclooxygenase-2 selective inhibitor, flosulide, on renal plasma flow and glomerular filtration rate in rats

[2] C Blume, et al. Kidney Int. Effect of flosulide, a selective cyclooxygenase 2 inhibitor, on passive heymann nephritis in the rat

[3] A S Lages, et al. Bioorg Med Chem Lett. Synthesis and pharmacological evaluation of new flosulide analogues, synthesized from natural safrole

[4] G Heise, et al. Nephron. Different actions of the cyclooxygenase 2 selective inhibitor flosulide in rats with passive Heymann nephritis

[5] W Zimmerli, et al. Biochem Pharmacol. Influence of the anti-inflammatory compound flosulide on granulocyte function

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