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FIIN-2

Cat. No. M5127
FIIN-2 Structure
Size Price Availability Quantity
5mg USD 110 In stock
10mg USD 180 In stock
25mg USD 360 In stock
50mg USD 600 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

In FGFR1-4 Ba/F3 cells, FIIN-2 inhibits cell proliferation with EC50 in the single- to double-digit nanomolar range. FIIN-2 also shows excellent antiproliferative activity in a variety of backgrounds, including cell lines that have gatekeeper mutations in FGFR1 and that are dependent on FGFR4.In a zebrafish developmental model, FIIN-2 causes mild or severe phenotypes to the tail morphogenesis by inhibiting FGFR.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 634.73
Formula C35H38N8O4
CAS Number 1633044-56-0
Purity >99%
Solubility Water <1 mg/mL
DMSO 69 mg/mL
Storage at -20°C
References

Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors.
Tan L,et.al. Proc Natl Acad Sci U S A. 2014 Nov 11;E4869-77. PMID: 25349422.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: FIIN-2 supplier, EGFR/HER2, inhibitors

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