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FICZ

Cat. No. M9087
FICZ Structure
Synonym:

6-Formylindolo[3,2-b]carbazole

Size Price Availability
5mg USD 500 1-2 Weeks
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

FICZ is a potent aryl hydrogen receptor (AhR) agonist. FICZ acts by inducing transient expression of cytochrome P450-1A1 (CYP1A1) in vitro. FICZ (10,000-30,000 nM) significantly decreases CEH viability with an estimated LC50 (95% confidence intervals) of 14,000 nM. FICZ shows concentration-dependent effects on EROD activity in CEH cultures, with the mean EC50 values at 3, 8, and 24 h of 0.016 nM, 0.80 nM, and 11 nM, respectively.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 284.31
Formula C19H10N2O
CAS Number 172922-91-7
Purity >98%
Solubility DMSO: 10 mg/mL (Need ultrasonic and warming)
Storage at -20°C
References

The highly bioactive molecule and signal substance 6-formylindolo[3,2-b]carbazole (FICZ) plays bi-functional roles in cell growth and apoptosis in vitro.
Mohammadi-Bardbori A, et al. Arch Toxicol. 2017 Oct;91(10):3365-3372. PMID: 28289825.

Time-dependent transcriptomic and biochemical responses of 6-formylindolo[3,2-b]carbazole (FICZ) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) are explained by AHR activation time.
Farmahin R, et al. Biochem Pharmacol. 2016 Sep 1;115:134-43. PMID: 27301797.

Biological effects of 6-formylindolo[3,2-b]carbazole (FICZ) in vivo are enhanced by loss of CYP1A function in an Ahr2-dependent manner.
Wincent E, et al. Biochem Pharmacol. 2016 Jun 15;110-111:117-29. PMID: 27112072.

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Keywords: FICZ, 6-Formylindolo[3,2-b]carbazole supplier, inhibitors

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