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FGF-401

Cat. No. M6095
FGF-401 Structure
Synonym:

FGF401; FGF 401

Size Price Availability Quantity
5mg USD 150 In stock
10mg USD 240 In stock
50mg USD 850 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

FGF-401 is a FGFR4 inhibitor developed for the treatment of solid tumor. FGF-401 is a FGFR4 inhibitor in phase I/II clinical studies for the treatment of positive FGFR4 and KLB expresion solid tumors and hepatocellular carcinoma.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 506.56
Formula C25H30N8O4
CAS Number 1708971-55-4
Purity >99%
Solubility 6 mg/mL in DMSO
Storage at -20°C
References

Comparing FK-506 with basic fibroblast growth factor (b-FGF) on the repair of a peripheral nerve defect using an autogenous vein bridge model.
Chaiyasate K, et al. J Invest Surg. 2009 Nov-Dec;22(6):401-5. PMID: 20001808.

Wnt/beta-catenin and Fgf signaling control collective cell migration by restricting chemokine receptor expression.
Aman A, et al. Dev Cell. 2008 Nov;15(5):749-61. PMID: 19000839.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: FGF-401, FGF401; FGF 401 supplier, FGFR, inhibitors

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