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Fenoldopam

Cat. No. M22322
Fenoldopam Structure
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Biological Activity

Fenoldopam

Chemical Information
Molecular Weight 305.76
Formula C16H16ClNO3
CAS Number 67227-56-9
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Annalisa Noce, et al. Curr Pharm Biotechnol. Fenoldopam Mesylate: A Narrative Review of Its Use in Acute Kidney Injury

[2] Michael A Gillies, et al. Crit Care. Fenoldopam to prevent acute kidney injury after major surgery-a systematic review and meta-analysis

[3] Muhammad Naeem, et al. Clin Imaging. Fenoldopam for the prevention of contrast-induced nephropathy (CIN)-do we need more trials? A meta-analysis

[4] R N Brogden, et al. Drugs. Fenoldopam: a review of its pharmacodynamic and pharmacokinetic properties and intravenous clinical potential in the management of hypertensive urgencies and emergencies

[5] A J Nichols, et al. Am J Hypertens. The pharmacology of fenoldopam

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