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Cat. No. M2253
Felbamate Structure


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10mg USD 60 In stock
50mg USD 200 In stock
100mg USD 330 In stock
200mg USD 500 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Felbamate (Felbatol) is an anticonvulsant, acting as an antagonist at the NMDA-associated glycine binding site. Felbamate is used in the treatment of epilepsy.

Customer Product Validations & Biological Datas
Source Epilepsy Behav (2017). Figure 4. Felbamate
Method Drug administration
Cell Lines Sprague–Dawley rats
Concentrations 3000 mg/rat
Incubation Time 5 d
Results In the absence of prior appetitive experience, a quite different pattern emerges, with the FBM-treated rats showing an acquisition deficit that persists throughout much of the training
Source Epilepsy Behav (2017). Figure 3. Felbamate
Method Drug administration
Cell Lines Sprague–Dawley rats
Concentrations 3000 mg/rat
Incubation Time 5 d
Results FBM-treated animals showed enhanced acquisition in the aversive context with prior appetitive training relative to controls
Cell Experiment
Cell lines Follicle cells
Preparation method Drug solutions were diluted into recording MBS from frozen stocks (NMDA, glycine) or dissolved from powder directly into MBS (felbamate, haloperidol) on the day of the experiment. Felbamate was dissolved in MBS to the highest concentration used (up to 3 mM) by heating to 50°C followed by vigorous stirring. The process was repeated once or twice, as necessary, until the felbamate dissolved.
Concentrations 1~3 mM
Incubation time 24 h
Animal Experiment
Animal models
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 238.24
Formula C11H14N2O4
CAS Number 25451-15-4
Purity >98%
Solubility DMSO 40 mg/mL
Storage at -20°C

Felbamate as an add-on therapy for refractory epilepsy.
Shi LL, et al. Cochrane Database Syst Rev. 2014 Jul 18;(7):CD008295. PMID: 25036694.

Subtype-selective antagonism of N-methyl-D-aspartate receptors by felbamate: insights into the mechanism of action.
Kleckner NW, et al. J Pharmacol Exp Ther. 1999 May;289(2):886-94. PMID: 10215667.

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Abmole Inhibitor Catalog 2017

Keywords: Felbamate, Felbatol supplier, GluR, inhibitors

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