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Cat. No. M10052
Fatostatin Structure

Fatostatin A

Size Price Availability Quantity
10mg USD 90  USD90 In stock
25mg USD 190  USD190 In stock
50mg USD 290  USD290 In stock
100mg USD 490  USD490 In stock
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Quality Control
Biological Activity

Fatostatin A is a cell permeable inhibitor of SREBP activation, it inhibits cancer cell proliferation by affecting mitotic microtubule spindle assembly and cell division.

Cell Experiment
Cell lines CHO-K1 cells
Preparation method CHO-K1 cells are plated out onto a 96-well plate in medium A. The cells are transiently cotransfected with pCMV-PLAP-BP2, pCMV-SCAP, and pAc-b-gal, using Lipofectamine reagent. After incubation for 5 hr, the cells are washed with PBS and then incubated in medium B, in the absence or presence of fatostatin (20 μM) or sterols (10 μg/mL cholesterol and 1 μg/mL 25-hydroxycholesterol). After 20 hr of incubation, an aliquot of the medium is assayed for secreted alkaline phosphatase activity. The cells in each well are lysed and used for measurement of b-galactosidase activities.
Concentrations 20 μM
Incubation time 20 h
Animal Experiment
Animal models Four-to-five-week-old homozygous male obese (ob/ob) mice
Formulation 10% DMSO in PBS
Dosages 30 mg/kg; 150 uL
Administration i.p. injection
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 294.41
Formula C18H18N2S
CAS Number 125256-00-0
Purity 99.76%
Solubility DMSO ≥ 30 mg/mL
Storage at -20°C

[1] Wei Shao, et al. J Lipid Res. Fatostatin blocks ER exit of SCAP but inhibits cell growth in a SCAP-independent manner

[2] Xiangyan Li, et al. Mol Cancer Ther. Fatostatin displays high antitumor activity in prostate cancer by blocking SREBP-regulated metabolic pathways and androgen receptor signaling

[3] Shinji Kamisuki, et al. Chem Biol. A small molecule that blocks fat synthesis by inhibiting the activation of SREBP

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Keywords: Fatostatin, Fatostatin A supplier, FAS, inhibitors

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