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Eupalitin

Cat. No. M16805
Eupalitin Structure
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Biological Activity

Eupalitin

Chemical Information
CAS Number 29536-41-2
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Mohammad Khalid, et al. Plants (Basel). Anti-Obesity Action of Boerhavia diffusa in Rats against High-Fat Diet-Induced Obesity by Blocking the Cannabinoid Receptors

[2] Kapil S Patil, et al. J Ethnopharmacol. Ethnomedicinal uses, phytochemistry and pharmacological properties of the genus Boerhavia

[3] Sarjeel Kaleem, et al. Cell Biol Int. Eupalitin induces apoptosis in prostate carcinoma cells through ROS generation and increase of caspase-3 activity

[4] Ruby Gupta, et al. Protoplasma. Advances in Boerhaavia diffusa hairy root technology: a valuable pursuit for identifying strain sensitivity and up-scaling factors to refine metabolite yield and bioactivity potentials

[5] Massimo Tacchini, et al. Nat Prod Res. Phytochemical profile and bioactivity of traditional ayurvedic decoctions and hydro-alcoholic macerations of Boerhaavia diffusa L. and Curculigo orchioides Gaertn

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