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Eucomol

Cat. No. M16826
Eucomol Structure
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Biological Activity

Eucomol

Chemical Information
CAS Number 17934-12-2
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] N M Shilina, et al. Vopr Med Khim. [Dynamics of malonic aldehyde, transferrin levels and blood antioxidant activity in women with normal pregnancy and pregnancy complicated by toxicosis: effect of eiconol]

[2] K A Masuev. Ter Arkh. [The effect of polyunsaturated fatty acids of the omega-3 class on the late phase of the allergic reaction in bronchial asthma patients]

[3] S B Malichenko, et al. Ter Arkh. [The effects of eiconol in elderly patients with non-insulin-dependent diabetes mellitus]

[4] A L Vertkin, et al. Kardiologiia. [Euconol in the treatment of patients with ischemic heart disease]

[5] M A Samsonov, et al. Vopr Med Khim. [Cholesterol metabolism in patients with ischemic heart disease with varying supplies of omega-3 polyunsaturated fatty acids]

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